Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes

AS Trigos; A Pasam; P Banks; R Wallace; C Guo; S Keam; H Thorne; C Mitchell; S Lade; D Clouston; A Hakansson; Y Liu; B Blyth; D Murphy; N Lawrentschuk; D Bolton; D Moon; P Darcy; Y Haupt; SG Williams; E Castro; D Olmos; D Goode; P Neeson; S Sandhu

Journal article

Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes

AS Trigos, A Pasam, P Banks, R Wallace, C Guo, S Keam, H Thorne, C Mitchell, S Lade, D Clouston, A Hakansson, Y Liu, B Blyth, D Murphy, N Lawrentschuk, D Bolton, D Moon, P Darcy, Y Haupt, SG Williams Show all

Journal for Immunotherapy of Cancer | BMJ PUBLISHING GROUP | Published : 2022

DOI: 10.1136/jitc-2021-003744

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Abstract

Background Aberrations in homologous recombination repair (HRR) genes are emerging as important biomarkers for personalized treatment in prostate cancer (PCa). HRR deficiency (HRD) could affect the tumor immune microenvironment (TIME), potentially contributing to differential responses to poly ADP-ribose polymerase (PARP) inhibitors and immune checkpoint inhibitors. Spatial distribution of immune cells in a range of cancers identifies novel disease subtypes and is related to prognosis. In this study we aimed to determine the differences in the TIME of PCa with and without germline (g) HRR mutations. Methods We performed gene expression analysis, multiplex immunohistochemistry of T and B cell..

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University of Melbourne Researchers

Anna Trigos Author

Heather Thorne Author

Catherine Mitchell Author

Benjamin Blyth Author

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Grants

Awarded by Peter MacCallum Foundation

Funding Acknowledgements

This study was funded by a Peter MacCallum Foundation grant, a Tolmar-ANZUP fellowship grant, and National Health and Medical Research Council grants (No. 2003115, 2003887).